Medically reregarded by Cynthia Cobb, DNP, APRN, WHNP-BC, FAANP — Written by James McIntosh on June 16, 2017

Collagen is the a lot of numerous protein in the huguy body, found in the bones, muscles, skin, and also tendons.

You are watching: What is the most abundant protein in the human body?


It is the substance that holds the body together. Collagen forms a scaffold to carry out toughness and structure.

Endogenous collagen is organic collagen, synthesized by the body. Exogenous collagen is man-made. It comes from an external resource, such as supplements.

Endogenous collagen has actually a variety of essential functions. Breakdvery own and also depletion is linked to a number of health troubles.

Exogenous collagen is offered for clinical and also cosmetic objectives, consisting of the repair of body tworries.


*
Share on PinterestCollagen has a sturdy framework. Gram-for-gram, some types are more powerful than steel.
Collagen is a tough, insoluble, and also fibrous protein that provides up one-3rd of the protein in the humale body.

In a lot of collagens, the molecules are packed together to develop lengthy, thin fibrils.

These act as supporting structures and also anchor cells to each other. They provide the skin strength and elasticity.

There are at leastern 16 various forms of collagen, yet 80 to 90 percent of them belengthy to forms 1, 2, and 3. These various types have actually different structures and functions.

The collagens in the humale body are solid and also versatile.

Type 1 collagen fibrils are specifically qualified of being stretched. Gram-for-gram, they are stronger than steel.


Roles: What does collagen do?

Collagen is secreted by various cells, but greatly by connective tconcern cells.

It is discovered in the extracellular matrix. This is an elaborate netoccupational of macromolecules that determines the physical properties of body tconcerns. A macromolecule is a molecule containing a huge number of atoms.


Share on PinterestWith age, collagen weakens, causing wrinkles and also cartilage troubles.

In the dermis, or the middle layer of skin, collagen helps create a fibrous network-related of cells dubbed fibroblasts, upon which brand-new cells deserve to grow. It additionally plays a function in replacing and restoring dead skin cells.

Some collagens act as protective coverings for fragile organs in the body, such as the kidneys.

With age, the body produces much less collagen. The structural integrity of the skin declines. Wrinkles form, and also joint cartilage weakens.

Womales endure a dramatic reduction in collagen synthesis after menopausage.

By the age of 60 years, a substantial decline in collagen production is normal.


Uses: Medical and cosmetic

Collagen is resorbable. This means it can be broken dvery own, converted, and also soaked up ago right into the body. It deserve to likewise be created right into compacted solids or lattice-prefer gels.

Its diverse variety of features and also the reality that it is normally emerging make it clinically flexible and suitable for assorted medical functions.

Collagen for clinical usage can originate from humans, cows, pigs, or lamb.

Skin fillers

Collagen injections deserve to improve the contours of the skin and fill out depressions.

Fillers that contain collagen can be supplied cosmetically to rerelocate lines and also wrinkles from the face. It have the right to additionally boost scars, as lengthy as these do not have a sharp edge.

These fillers are sourced from people and also cows. Skin tests must be done before making use of collagen from cows, to avoid aggravating any kind of allergies.

Collagen deserve to fill fairly superficial quantities. More extensive gaps are typically filled via substances such as fat, silicone, or implants.

Wound dressing

Collagen can help heal wounds by attracting brand-new skin cells to the wound site. It promotes healing and provides a platdevelop for new tproblem development.

Collagen dressings can assist heal:

chronic wounds that perform not respond to various other treatmentwounds that expel bodily fluids such as urine or sweatgranulating wounds, on which different tconcern growsnecrotic or rotting woundspartial and full-thickness woundssecond-degree burnssites of skin donation and also skin grafts

Collagen dressings are not recommfinished for third-degree burns, wounds covered in dry eschar, or for patients that might be sensitive to products sourced from cows.

Guided tproblem regeneration

Collagen-based membranes have been supplied in periodontal and implant therapy to promote the expansion of certain kinds of cell.

In oral surgical treatment, collagen obstacles have the right to proccasion fast-prospering cells roughly the gum from moving to a wound in a tooth. This preserves a room where tooth cells have actually the opportunity to regenerate.

Collagen-based membranes deserve to assist healing in these cases and they are resorbable, so this obstacle does not have to be surgically rerelocated after the main procedure.

Vascular prosthetics

Collagen tproblem grafts from donors have been used in peripheral nerve rebirth, in vascular prostheses, and in arterial rebuilding and construction.

While collagen prostheses are compatible through the humale body, some have been found to be thrombogenic, or most likely to reason coagulation of the blood.

Treatment of osteoarthritis

Collagen supplements or formulations might help treat osteoarthritis.

A 2006 testimonial found that supplements containing collagen aided decrease painful symptoms and boosting joint attribute in people through osteoarthritis.

As the supplement was absorbed, collagen gathered in the cartilage, and also this assisted to redevelop the extracellular matrix.

Not all research studies have supported these findings, however.

Skin revitalization


Share on PinterestCollagen creams are unmost likely to job-related, as collagen molecules are too huge to pass through the skin.

Many products containing collagen, consisting of creams and powders, claim to revitalize the skin by boosting collagen levels within the body.

This is unlikely, yet, as collagen molecules are as well big to be absorbed via the skin.

Any advantage is most likely due to the moisturizing results of these commodities. They do not straight increase collagen.

Such therapies are also not classified as drugs, so any type of clintends concerning their efficacy do not should be scientifically prrange. Caution is advised when using these commodities.


Laser therapy deserve to help treat stretch marks, as it can stimulate the expansion of collagen, elastin, and also melanin.

A healthful diet deserve to help the body create collagen.

Nutrients that may assistance collagen development include:

Copper: In shellfish, nuts, red meat, and some drinking water.

What damages collagen?

Some components have the right to diminish the levels of collagen within the body. Avoiding them could store the skin healthy for much longer.

High sugar consumption: A high-sugar diet rises the price of glycation, a process wright here blood sugars affix to proteins to create brand-new molecules dubbed advanced glycation finish assets (AGEs).

AGEs damages adjacent proteins and have the right to make collagen dry, brittle, and weak.

Smoking: Many kind of chemicals present in tobacco smoke damage both collagen and also elastin in the skin.

Nicotine also narrows the blood vessels in the external layers of the skin. This comguarantees skin health by reducing the shipment of nutrients and oxygen to the skin.

Sunlight: Ultraviolet rays in sunlight reason collagen to break dvery own more quickly, damaging collagen fibers and also leading to abnormal elastin to develop up.

The UV rays in sunlight damages the collagen in the dermis, and also the skin rebuilds mistakenly, creating wrinkles.

Autoimmune disorders: Some autoimmune disorders reason antibodies to targain collagen.

Genetic changes can impact the extracellular matrix. The collagen that is produced deserve to be reduced, or it may be dysuseful, mutated collagen.

The aging process causes collagen levels to deplete normally over time. Tbelow is no method to prevent this.

See more: The Basic Difference Between The Short Run And The Long Run Is That:

Avoiding tobacco and excess sun expocertain and also complying with a healthful dietary and also exercise program deserve to aid reduce visible aging and defend collagen, keeping the skin, bones, muscles, and also joints healthy and balanced for much longer.