(Cicatricial Pemphigoid; Ocular Cicatricial Pemphigoid; Benign Mucous Membrane Pemphigoid)


Melvin I. Roat

, MD, FACS, Sidney Kimmel Medical College at Thomas Jefferkid University

You are watching: Inflammation of the mucosa lining the eyelids


(See also Outline of Conjunctival and also Scleral Disorders Rundown of Conjunctival and Scleral Disorders The conjunctiva is the membrane that lines the eyelid and also loops back to cover the sclera (the tough white fiber layer extending the eye), right as much as the edge of the cornea (the clear layer in... read more and also Mucous Membrane Pemphigoid Mucous Membrane Pemphigoid Mucous membrane pemphigoid is an autoimmune disorder that reasons blisters to develop in the mucous membranes of the body. The mucous membranes most often impacted are the mouth and eyes. Mucous... check out more .)

Ocular mucous membrane pemphigoid is an autoimmune disorder Autoimmune Disorders An autoimmune disorder is a breakdown of the body"s immune system that reasons the body to attack its very own tproblems. What triggers autoimmune disorders is not recognized. Symptoms differ depending upon... read even more (a breakdown of the body"s immune device Summary of the Immune System The immune system is designed to safeguard the body versus international or dangerous invaders. Such invaders encompass Microorganisms (commonly referred to as germs, such as bacteria, viroffers, and fungi) Parasites... read even more that reasons the body to strike its very own tissues). It reasons inflammation that starts in the conjunctiva (the membrane that lines the eyelid and also covers the white of the eye). This disorder deserve to additionally impact various other mucous membranes of the body.


In civilization with ocular mucous membrane pemphigoid, both eyes are influenced, ending up being red at first. Later, the conjunctiva shrinks, making it challenging to pull the top or lower eyelid away from the eye. Much later, the eyes become dry.

The cornea (the clear layer in front of the iris and also pupil) can become cloudy, avoiding light from getting to the retina and decreasing vision.

The conjunctiva have the right to svehicle and also shrink, leading to eyelashes to rotate inward (check out Trichiasis Trichiasis Trichiasis is misalignment of eyelashes, which rub versus the eyeball, in a perkid who does not have entropion. Trichiasis develops a lot of frequently some time after chronic blepharitis (inflammation... read more ) and also better damages the cornea.

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Doctors commonly suspect the diagnosis of ocular mucous membrane pemphigoid based on the person"s symptoms and also the results of an eye examicountry, including an examicountry through a slit lamp Slit-Lamp Examination A perchild that has eye symptoms must be checked by a medical professional. However, some eye disorders reason few or no symptoms in their early on steras, so the eyes must be checked frequently (every 1 to 2... check out even more (an instrument that permits a doctor to examine the eye under high magnification). The diagnosis is typically evidenced by a conjunctival biopsy. In this kind of biopsy, a sample of the conjunctiva is rerelocated and also examined under a microscope.

People with ocular mucous membrane pemphigoid have the right to usage synthetic tears and also physicians deserve to remove inwardly turned lashes (for example, by pulling, freezing, or burning through electricity) to aid relieve symptoms and also proccasion some complications. If the illness progresses, a drug that suppresses the immune device, such as dapsone, methotrexate, mycophenolate mofetil, or cyclophosphamide, is essential.